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We previously reported the involvement of protein arginine methyltransferase 1 (PRMT1) in adipocyte thermogenesis. Here, we investigate the effects of PRMT1 inhibitors on thermogenesis. Unexpectedly, we find that the PRMT1 inhibitor TC‐E 5003 (TC‐E) induces the thermogenic properties of primary murine and human subcutaneous adipocytes. TC‐E treatment upregulates the expression of Ucp1 and Fgf21 significantly...
Cinnamaldehyde (CA) is a food compound that has previously been observed to be protective against obesity and hyperglycemia in mouse models. In this study, we aimed to elucidate the mechanisms behind this protective effect by assessing the cell-autonomous response of primary adipocytes to CA treatment.Primary murine adipocytes were treated with CA and thermogenic and metabolic responses were assessed...
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