Search results for: Lynne Stecher

Items from 1 to 12 out of 12 results

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Infant growth during the first year of life following a pregnancy lifestyle intervention in routine care—Findings from the cluster‐randomised GeliS trial

Julia Hoffmann, Julia Günther, Lynne Stecher, Monika Spies, more

Background Lifestyle interventions in pregnancy may influence postpartum development and obesity risk in offspring. The impact of lifestyle interventions as health system‐based approaches is unclear. Objective To evaluate the effect of an antenatal lifestyle intervention conducted as public health approach on infant development and feeding practices. Methods We followed offspring born to women...

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Effects of a lifestyle intervention in routine care on prenatal physical activity – findings from the cluster-randomised GeliS trial

Julia Hoffmann, Julia Günther, Kristina Geyer, Lynne Stecher, more

BMC Pregnancy and Childbirth > 2019 > 19 > 1 > 1-13

Background Excessive gestational weight gain (GWG) is associated with an increased risk of pregnancy and obstetric complications. The “healthy living in pregnancy” (GeliS) study was performed in a routine care setting with the aim of limiting excessive GWG. The purpose of this secondary analysis is to evaluate the effect of the intervention on physical activity (PA) behaviour and to assess the impact...

article

Adipose Mitochondrial Respiratory Capacity in Obesity is Impaired Independently of Glycemic Status of Tissue Donors

Britta Wessels, Julius Honecker, Theresa Schöttl, Lynne Stecher, more

Obesity > 27 > 5 > 756 - 766

Objective The study aimed to investigate how obesity and glycemic state affect mitochondrial respiration and ATP–generating pathways in mature human adipocytes. Methods Subcutaneous (sc) and visceral (vc) adipocytes were isolated from patients undergoing abdominal surgery. Respiratory chain function was analyzed by high‐resolution respirometry. Adipocyte ATP levels and lactate release were measured...

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Do lifestyle interventions during pregnancy have the potential to reduce long‐term postpartum weight retention? A systematic review and meta‐analysis

Sophie Michel, Roxana Raab, Theresa Drabsch, Julia Günther, more

Obesity Reviews > 20 > 4 > 527 - 542

Reducing postpartum weight retention is a promising strategy for addressing the rising prevalence of overweight and obesity in women. This systematic review and meta‐analysis explored whether lifestyle interventions during pregnancy have the potential to reduce weight retention at 4 months postpartum and beyond. A search of five electronic databases for randomized controlled trials comparing the effect...

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Effects of a lifestyle intervention during pregnancy to prevent excessive gestational weight gain in routine care – the cluster-randomised GeliS trial

Julia Kunath, Julia Günther, Kathrin Rauh, Julia Hoffmann, more

BMC Medicine > 2019 > 17 > 1 > 1-13

Background Excessive gestational weight gain (GWG) leads to obstetric complications, maternal postpartum weight retention and an increased risk of offspring obesity. The GeliS study examines the effect of a lifestyle intervention during pregnancy on the proportion of women with excessive GWG and pregnancy and obstetric complications, as well as the long-term risk of maternal and infant obesity. ...

article

Sustained low efficiency dialysis should not be interrupted for performing transpulmonary thermodilution measurements

Stefanie Geith, Lynne Stecher, Christian Rabe, Stefan Sack, more

Annals of Intensive Care > 2018 > 8 > 1 > 1-13

Background Treatment of multiple organ failure frequently requires enhanced hemodynamic monitoring. When renal replacement is indicated, it remains unclear whether transpulmonary thermodilution (TPTD) measurements are influenced by renal replacement therapy (RRT) and whether RRT should be paused for TPTD measurements. Our aim was therefore to investigate the effect of pausing RRT on TPTD results in...

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Leptin in Maternal Plasma and Cord Blood as a Predictor of Offspring Adiposity at 5 Years: A Follow‐up Study

Dorothy Marie Meyer, Christina Brei, Lynne Stecher, Daniela Much, more

Obesity > 26 > 2 > 279 - 283

Objective Perinatal leptin exposure may modulate the risk of adiposity in early childhood. In previous analyses, negative associations between maternal (32 weeks' gestation) and cord blood leptin and offspring body composition at 2 years were observed. Methods Associations between maternal/cord blood leptin were assessed with indirect (i.e., body weight, BMI percentiles, sum of 4 skinfold thicknesses),...

article

Long-Term Outcomes After MitraClip Implantation According to the Presence or Absence of EVEREST Inclusion Criteria

Hasema Lesevic, Michael Karl, Daniel Braun, Petra Barthel, more

The American Journal of Cardiology > 2017 > 119 > 8 > 1255-1261

Numerous patients are treated with the MitraClip, although they do not fulfill the stringent inclusion criteria of the Endovascular Valve Edge-to-Edge Repair Study (EVEREST) trials. The outcome of those patients is not well known. Therefore, we compared the long-term outcome after MitraClip treatment between patients who matched (group 1) and did not match (group 2) the EVEREST criteria. One hundred...

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Shared decision making PLUS – a cluster-randomized trial with inpatients suffering from schizophrenia (SDM-PLUS)

Johannes Hamann, Fabian Holzhüter, Lynne Stecher, Stephan Heres

BMC Psychiatry > 2017 > 17 > 1 > 1-9

Background Shared decision making (SDM) is a model of how doctors and patients interact with each other. It aims at changing the traditional power asymmetry between doctors and patients by strengthening the exchange of information and the decisional position of the patient. Although SDM is generally welcomed by mental health patients as well as by mental health professionals its implementation in...

article

The SWITCH study: rationale and design of the trial

Stephan Heres, Diana Meliu Cirjaliu, Liana Dehelean, Valentin Petre Matei, more

European Archives of Psychiatry and Clinical Neuroscience > 2016 > 266 > 6 > 513-521

Many patients do not respond to the first antipsychotic drug prescribed, but require multiple trials with different drugs before response is achieved. Current treatment guidelines vary substantially in their recommendations as to how long clinicians should wait before an antipsychotic treatment attempt should be considered as failed and the compound switched. It has, however, recently been shown that...

article

Excessive gestational weight gain prior to glucose screening and the risk of gestational diabetes: a meta-analysis

Stefanie Brunner, Lynne Stecher, Stephanie Ziebarth, Ina Nehring, more

Diabetologia > 2015 > 58 > 10 > 2229-2237

Aims/hypothesis Excessive gestational weight gain (GWG) may be a risk factor for gestational diabetes mellitus (GDM). We aimed to study the association between excessive GWG (defined according to Institute of Medicine recommendations) prior to GDM screening, and GDM. Methods We systematically searched four electronic databases from 1990 until September 2014 for observational studies published in...

article

Lifestyle intervention to prevent excessive maternal weight gain: mother and infant follow-up at 12 months postpartum

Kathrin Rauh, Julia Günther, Julia Kunath, Lynne Stecher, more

BMC Pregnancy and Childbirth > 2015 > 15 > 1 > 1-11

Background Excessive gestational weight gain (GWG) is associated with elevated weight retention in mothers and might be related to adiposity of their offspring. Little is known if lifestyle intervention during pregnancy has beneficial effects for mothers and children beyond gestation. Methods A cluster-randomized controlled intervention trial was performed with 250 pregnant women in 8 gynaecological...

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