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The effect of a two-week desipramine or fluoxetine (10mg/kg, i.p.) pretreatment on B16F10 melanoma growth in 3–5month old female and male C57BL/6J mice differing in behavioral characteristics (high- vs. low-active) was compared. Antidepressant pretreatment increased metastasis formation, shortened the survival, decreased splenocyte anti-tumor natural killer cell cytotoxicity (in vitro), and the pro-inflammatory...
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