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Pituitary adenomas are common neoplasms. Initially considered as sporadic tumours, some of them are associated with familial syndromes such as familial isolated pituitary adenoma, multiple endocrine neoplasia type 1 and type 4, X-linked acrogigantism syndrome, Carney complex, pheochromocytoma/paraganglioma–pituitary adenoma, pituitary blastoma and McCune–Albright syndrome. They represent a group of...
Individuals harboring germ-line DICER1 mutations are predisposed to a rare cancer syndrome, the DICER1 Syndrome or pleuropulmonary blastoma-familial tumor and dysplasia syndrome [online Mendelian inheritance in man (OMIM) #601200]. In addition, specific somatic mutations in the DICER1 RNase III catalytic domain have been identified in several DICER1-associated tumor types. Pituitary blastoma (PitB)...
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