Stefano R. Giannubilo

article

Pre‐eclampsia onset and SPARC: A possible involvement in placenta development

Giovanni Tossetta, Sonia Fantone, Stefano R. Giannubilo, Elena Marinelli Busilacchi, more

Journal of Cellular Physiology > 234 > 5 > 6091 - 6098

Pre‐eclampsia (PE) is a multisystem disorder commonly diagnosed in the latter half of pregnancy and it is a leading cause of intrauterine fetal growth retardation (IUGR). The aim of this study was to investigate the localization and the role of SPARC, secreted protein acidic, and rich in cysteine, in PE and PE–IUGR placentas in comparison with normal placentas. SPARC was mainly expressed in the villous...

article

Omega‐3 fatty acids modulate the lipid profile, membrane architecture, and gene expression of leiomyoma cells

Md Soriful Islam, Clara Castellucci, Rosamaria Fiorini, Stefania Greco, more

Journal of Cellular Physiology > 233 > 9 > 7143 - 7156

Uterine leiomyomas (fibroids or myomas) are the most common benign tumors of premenopausal women and new medical treatments are needed. This study aimed to determine the effects of omega‐3 fatty acids on the lipid profile, membrane architecture and gene expression patterns of extracellular matrix components (collagen1A1, fibronectin, versican, or activin A), mechanical signaling (integrin β1, FAK,...

article

The effect of astaxanthin on the aging rat brain: gender‐related differences in modulating inflammation

Marta Balietti, Stefano R Giannubilo, Belinda Giorgetti, Moreno Solazzi, more

Journal of the Science of Food and Agriculture > 96 > 2 > 615 - 618

BACKGROUNDAstaxanthin (Ax) is a ketocarotenoid of the xanthophyll family with activities such as antioxidation, preservation of the integrity of cell membranes and protection of the redox state and functional integrity of mitochondria. The aim of this study was to investigate potential gender‐related differences in the effect of Ax on the aging rat brain. RESULTSIn females, interleukin 1 beta (IL1...

article

Noninvasive Fetal Electrocardiography: An Overview of the Signal Electrophysiological Meaning, Recording Procedures, and Processing Techniques

Angela Agostinelli, Marla Grillo, Alessandra Biagini, Corrado Giuliani, more

Annals of Noninvasive Electrocardiology > 20 > 4 > 303 - 313

BackgroundNoninvasive fetal electrocardiography (fECG), obtained positioning electrodes on the maternal abdomen, is important in safeguarding the life and the health of the unborn child. This study aims to provide a review of the state of the art of fECG, and includes a description of the parameters useful for fetus clinical evaluation; of the fECG recording procedures; and of the techniques to extract...

article

Potential role of Klotho protein in the pathophysiology of preeclampsia

Monia Cecati, Stefano R. Giannubilo, Alessandra Corradetti, Monica Emanuelli, more

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2015 > 5 > 1 > 152-153

An aging-suppressor gene, klotho, is a candidate factor for vascular disease because its deficiency leads to impaired endothelium-dependent vasodilation and impaired angiogenesis.The aim was to verify a possible relation among the expression of the klotho gene, single nucleotide polymorphisms (SNP) in the promoter region, and placenta aging.Placentas were collected from normal pregnancies (n=34) and...

article

Management of leiomyomas in perimenopausal women

Pasquapina Ciarmela, Andrea Ciavattini, Stefano R. Giannubilo, Pasquale Lamanna, more

Maturitas > 2014 > 78 > 3 > 168-173

Uterine leiomyomas, commonly called fibroids, are the leading indication for hysterectomy in the United States. Incidence increases with age from menarche to perimenopause. Regardless of their generally benign neoplastic character, uterine fibroids are responsible for significant morbidity in a large proportion of women of reproductive age.As uterine leiomyomas generally regress after menopause, the...

article

Preeclampsia: No longer solely a pregnancy disease

Andrea L. Tranquilli, Beatrice Landi, Stefano R. Giannubilo, Baha M. Sibai

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2012 > 2 > 4 > 350-357

Preeclampsia, the leading cause of maternal and perinatal morbidity and mortality, has been recently considered not only a pregnancy disease but also a risk factor for developing diseases later in life. Preeclampsia is becoming a disease of interest to internists and not just obstetricians. Women who have had preeclampsia seem to be at higher risk of premature death, mortality from ischemic heart...

article

The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage

Stefano R. Giannubilo, Beatrice Landi, Valentina Pozzi, Davide Sartini, more

Cytokine > 2012 > 58 > 1 > 50-56

To investigate the inflammatory cytokine expression pattern in trophoblastic tissue from women with unexplained recurrent miscarriage (RM).Trophoblasts were obtained during uterine evacuation from 11 women with RM and from 20 healthy pregnant women undergoing elective termination of pregnancy, who served as controls. The array was performed using GEArray Q Series Human Inflammatory Cytokines &...

article

Nifedipine versus labetalol in the treatment of hypertensive disorders of pregnancy

Stefano R. Giannubilo, Valeria Bezzeccheri, Stefano Cecchi, Beatrice Landi, more

Archives of Gynecology and Obstetrics > 2012 > 286 > 3 > 637-642

Purpose To assess the maternal and fetal outcomes of pregnancies affected by hypertensive disorders treated with nifedipine versus labetalol. Methods A retrospective study in hypertensive patients treated during pregnancy with nifedipine or labetalol was conducted. After the charts review the patients were divided in the four groups: gestational hypertension (113 patients); mild preeclampsia (77...

article

Placental expression of endothelial and inducible nitric oxide synthase and nitric oxide levels in patients with HELLP syndrome

Laura Mazzanti, Monia Cecati, Arianna Vignini, Sara D'Eusanio, more

American Journal of Obstetrics and Gynecology > 2011 > 205 > 3 > 236.e1-236.e7

To determine placental gene expression of endothelial and inducible nitric oxide synthases and measure nitric oxide levels in patients with hemolysis, elevated liver enzyme levels, and low platelet count syndrome.Preterm placentas were obtained from 15 patients with hemolysis, elevated liver enzyme levels, and low platelet count syndrome and 30 controls matched for age, parity, and gestational age...

article

HLA-G and pregnancy adverse outcomes

Monia Cecati, Stefano R. Giannubilo, Monica Emanuelli, Andrea L. Tranquilli, more

Medical Hypotheses > 2011 > 76 > 6 > 782-784

There is growing evidence that pregnancy complications such as preeclampsia, recurrent pregnancy loss (RPL), IUGR, and premature birth could be associated with abnormal immunologic interactions at the fetal–maternal interface. The restricted expression of HLA-G to the subpopulation of trophoblast cells which invade the uterus has generated much interest. The alternative splicing of HLA-G primary transcript,...

article

710: Inflammatory cytokines pattern in recurrent miscarriage

Stefano R. Giannubilo, Beatrice Landi, Valentina Pozzi, Raffaella Raffio, more

American Journal of Obstetrics and Gynecology > 2011 > 204 > 1 Supplement > S280

article

428: Apoptosis pathway is involved in hemolysis, elevated liver enzyme, and low platelet (HELLP) syndrome and intrauterine growth restriction (IUGR)

Monia Cecati, Stefano R. Giannubilo, Valentina Pozzi, Davide Sartini, more

American Journal of Obstetrics and Gynecology > 2011 > 204 > 1 Supplement > S173

article

M14.4 Placental expression of endothelial and inducible nitric oxide synthase and nitric oxide levels in patients with HELLP syndrome

Laura Mazzanti, Monia Cecati, Arianna Vignini, Monica Emanuelli, more

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2010 > 1 > Supplement 1 > S12

article

The role of p38α mitogen-activated protein kinase gene in the HELLP syndrome

Alessandra Corradetti, Franca Saccucci, Monica Emanuelli, Giorgia Vagnoni, more

Cell Stress and Chaperones > 2010 > 15 > 1 > 95-100

Mitogen-activated protein kinase (MAPK) p38α was shown to be implicated in the organogenesis of the placenta, and such placental alteration is crucial for the development of hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. We aimed to analyze for the first time human placental expression of MAPK p38α in pregnancies complicated by HELLP. The placental expression of MAPK p38α was...

article

Placental Alpha Hemoglobin Stabilizing Protein (AHSP) and recurrent miscarriage

Monica Emanuelli, Monia Cecati, Davide Sartini, Piergiorgio Stortoni, more

Cell Stress and Chaperones > 2009 > 14 > 2 > 193-197

AHSP inhibits cellular production of the reactive oxygen species. Reduced AHSP indicates reduced protection against oxidative stressors. Our objective was to investigate AHSP levels in recurrent miscarriage (RM). Trophoblast was collected from women of 10 weeks gestation: voluntary abortion controls (VA, n = 10); spontaneous first miscarriage with subsequent normal pregnancy (SMSN, n = 15) or with...

article

Inflammatory cytokines patterns in the placenta of pregnancies complicated by HELLP (hemolysis, elevated liver enzyme, and low platelet) syndrome

Andrea L. Tranquilli, Beatrice Landi, Alessandra Corradetti, Stefano R. Giannubilo, more

Cytokine > 2007 > 40 > 2 > 82-88

Objective: We investigated the expression pattern and the role of inflammatory cytokines and their receptors in the placentas of pregnancy with HELLP syndrome. Study design: Placentas were collected after cesarean section, 10 from normal pregnancy and 10 from HELLP. The array was performed with GEArray Q Series Human Inflammatory Cytokines & Receptors Gene Array HS-015. The data were confirmed...

article

Adverse pregnancy outcomes are associated with multiple maternal thrombophilic factors

Andrea L. Tranquilli, Stefano R. Giannubilo, Bernardo Dell’Uomo, Elvira Grandone

European Journal of Obstetrics and Gynecology > 2004 > 117 > 2 > 144-147

Objective: To determine to what extent adverse pregnancy outcomes are associated with thrombophilia. Study design: We studied 31 women who had HELLP syndrome, placental abruption, fetal growth restriction or unexplained stillbirth (study group), matched with 12 controls. All women were tested for: Factor V, Prothrombin, methylenetetrahydrofolate reductase gene (MTHFR) mutations; for Protein C, S and...

article

Amniotic levels of nitric oxide and vascular endothelial growth factor in pregnancy with subsequent intrauterine fetal death

Andrea L. Tranquilli, Stefano R. Giannubilo, Valeria Bezzeccheri, Andrea Ciavattini, more

European Journal of Obstetrics and Gynecology > 2004 > 114 > 2 > 162-165

Objective: Nitric oxide (NO) and vascular endothelial growth factor (VEGF) regulate angiogenesis and seem involved in the early stages of placentation. If angiogenesis is reduced, this may lead to poor placentation and fetal death. This study was aimed to determine whether VEGF and NO are associated to subsequent fetal death. Study design: We retrospectively assessed NO and VEGF on midtrimetster amniotic...

article

Amniotic vascular endothelial growth factor (VEGF) and nitric oxide (NO) in women with subsequent preeclampsia

Andrea L. Tranquilli, Valeria Bezzeccheri, Stefano R. Giannubilo, Caterina Scagnoli, more

European Journal of Obstetrics and Gynecology > 2004 > 113 > 1 > 17-20

Objective: To assess whether amniotic fluid concentrations of nitric oxide (NO) and vascular endothelial growth factor (VEGF) in early pregnancy correlate to subsequent preeclampsia. Study design: We performed a retrospective study to assess VEGF and NO on the second trimester amniotic fluid of 15 healthy women, and 15 women who subsequently developed preeclampsia. Results: In women with subsequent...

INFONA - science communication portal

Search results for: Stefano R. Giannubilo

Pre‐eclampsia onset and SPARC: A possible involvement in placenta development

Omega‐3 fatty acids modulate the lipid profile, membrane architecture, and gene expression of leiomyoma cells

The effect of astaxanthin on the aging rat brain: gender‐related differences in modulating inflammation

Noninvasive Fetal Electrocardiography: An Overview of the Signal Electrophysiological Meaning, Recording Procedures, and Processing Techniques

Potential role of Klotho protein in the pathophysiology of preeclampsia

Management of leiomyomas in perimenopausal women

Preeclampsia: No longer solely a pregnancy disease

The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage

Nifedipine versus labetalol in the treatment of hypertensive disorders of pregnancy

Placental expression of endothelial and inducible nitric oxide synthase and nitric oxide levels in patients with HELLP syndrome

HLA-G and pregnancy adverse outcomes

710: Inflammatory cytokines pattern in recurrent miscarriage

428: Apoptosis pathway is involved in hemolysis, elevated liver enzyme, and low platelet (HELLP) syndrome and intrauterine growth restriction (IUGR)

M14.4 Placental expression of endothelial and inducible nitric oxide synthase and nitric oxide levels in patients with HELLP syndrome

The role of p38α mitogen-activated protein kinase gene in the HELLP syndrome

Placental Alpha Hemoglobin Stabilizing Protein (AHSP) and recurrent miscarriage

Inflammatory cytokines patterns in the placenta of pregnancies complicated by HELLP (hemolysis, elevated liver enzyme, and low platelet) syndrome

Adverse pregnancy outcomes are associated with multiple maternal thrombophilic factors

Amniotic levels of nitric oxide and vascular endothelial growth factor in pregnancy with subsequent intrauterine fetal death

Amniotic vascular endothelial growth factor (VEGF) and nitric oxide (NO) in women with subsequent preeclampsia

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Stefano R. Giannubilo

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options