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In article number 1806727, Wilfried Weber and co‐workers present a synthetic extracellular matrix, the mechanical properties of which can be tuned in a fast and reversible manner by light in the red spectrum. They apply this matrix to optically control the migration of primary T lymphocytes and to analyze mechanosignalling in mesenchymal stem cells in response to dynamic mechanical cues. Cover image...
Interrogation and control of cellular fate and function using optogenetics is providing revolutionary insights into biology. Optogenetic control of cells is achieved by coupling genetically encoded photoreceptors to cellular effectors and enables unprecedented spatiotemporal control of signaling processes. Here, a fast and reversibly switchable photoreceptor is used to tune the mechanical properties...
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