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Effects of the NK 1 receptor antagonist CP-99,994 on nicotine-induced emesis were examined inSuncus murinus . CP-99,994 (3 and 10 mg/kg i.p.) attenuated emesis to (-)nicotine (4 mg/kg s.c.). CP-100,263 (3 and 10 mg/kg i.p.), the enantiomer of CP-99,994 with 1000 fold lower affinity for the NK 1 receptor was without effect and RP67580 reduced emesis only at a dose of 30 mg/kg i.p...
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