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We have investigated functional connectivity of the default mode network (DMN) in normal aging and Alzheimer's disease (AD) using resting state fMRI at 3T. Images from young and elderly controls, and patients with AD were processed using spatial independent component analysis to identify the DMN. Functional connectivity was quantified using integration and indices derived from graph theory. Four DMN...
The hippocampus is among the first structures affected in Alzheimer's disease (AD); hippocampal MRI volumetry is a potential biomarker for AD but is hindered by the limitations of manual segmentation. We propose a fully automatic method using probabilistic and anatomical priors for hippocampus segmentation. Probabilistic information is derived from 16 young controls and anatomical knowledge is modeled...
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