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A short enantioselective synthesis of barrenazines A and B is described. Barrenazines A and B are prepared following a common synthetic route in nine steps (19% overall yield) and eight steps (21% overall yield), respectively, from readily available 4-methoxy-3-(triisopropylsilyl)pyridine. The synthesis relies on a highly diastereoselective nucleophilic addition of a Grignard reagent to a chiral acylpyridinium...
A practical and efficient stereoselective synthesis of the side chain of neomarinone is reported. The synthesis was achieved in six steps (41% overall yield) from 2-methyl-2-cyclohexenone. The key step is a novel stereoselective 1,4-conjugate addition/enolate alkylation by an epoxide-opening reaction.
The synthesis of vitamin D 3 active metabolites [24R,25-(OH) 2 -D 3 , 24S,25-(OH) 2 -D 3 and 1α,24R,25-(OH) 3 -D 3 ] and the first 24-aminovitamin D 3 derivatives [24S-benzoylamino-25-OH-D 3 and 24S-benzoylamino-1α,25-(OH) 2 -D 3 ] are reported. The stereogenic center at C-24 was generated through ultrasonically...
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