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Despite the advent of effective oral therapies for erectile dysfunction (ED), many patients are not successfully treated, and side effects have been documented.To further evaluate the potential utility of naked DNA-based gene transfer as an attractive treatment option for ED.The effects of gene transfer on erectile function and sexual behavior were evaluated in eight male cynomolgus monkeys with ED...
Erectile dysfunction is a common diabetic complication. Preclinical studies have documented that the Slo gene (encoding the BK or Maxi-K channel α-subunit) plays a critical role in erectile function. Therefore, we determined whether diabetes induces changes in the splicing of the Slo gene relevant to erectile function.Reverse transcriptase-polymerase chain reaction was used to compare Slo splice variant...
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