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Creatine is alleged to be a popular nutrition to enhance sports performance. It can be metabolized to methylamine, which is further converted to formaldehyde, hydrogen peroxide and ammonium by semicarbazied-sensitive amine oxidases (SSAO). Until now, there is no scientific available data for demonstration the long-term health risks of chronic creatine ingestion. In this study, we demonstrated that...
The dopamine-derived salsolinol (Sal), 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, has been considered a potential endogenous neurotoxin involved in the etiology of PD. In the present study, 150 muM dopamine (DA) was applied to be the treatment concentration on account of that 150 muM DA decreased cell viability to 44.8%. The level of salsolinol in human dopaminergic SH-SY5Y cells treated...
The peak compression effect induced by velocity difference has been theoretically and experimentally established. L-tryptophan and 2-nitrophenol were used as model compounds. The peak compression of L-tryptophan and 2-nitrophenol was obtained by the difference of its migration velocity along the column induced by the adjustment of composition of mobile phase. A compression of analytes peak and reduced...
The enantiomers of three chiral compounds of neural interest, N-(2-heptyl)propargylamine (2-HPA), 2-heptylamine (2-HA) and 2-HPPA were separated analytically using capillary electrophoresis (CE) with cyclodextrin chiral selectors. And dansyl chloride was chosen as the reagent for pre-column derivation to give 2-HPA derivatives. The effects of pH, beta-CD concentration, electrolyte concentration and...
HPLC was used to separate chiral compounds with chiral column. Another method was used in HPLC with chiral mobile phase additives to separate chiral compounds. Using chiral mobile phase additives is a good way to separate the chiral compounds. The structure of the derivative takes an important role in separation. We derivatized 2-heptamine with benzene sulfonyl chloride and dansyl chloride, Using...
A UV method was established to determination the total flavonoids in extractive solution from Torreya grandis Fort, leaves, and a RP-HPLC method was developed and validated to quantify 4', 5, 7-Trihydroxyflavone- 5- O- [alpha- L- Rhamno-pyranosyl- (1rarr4)- 6- O- acetyl- beta- D- glucopyranoside] (FRG). The dried leaf samples were extracted using methanol. The extracts were directly analyzed, without...
To evaluate the influence of Konjac glucomannan (KGM) on assaying domperidone in orally disintergrating tablets, We established an RP-HPLC method for the determination of domperidone in dompoeridone orally disintergrating tablets. Then KGM was added to the prescription. Good resolution was obtained after the sample was destroyed by acid, alkali and heat. The results suggested that KGM had the potential...
Phytochemical investigation of Thesium chinense Turcz, led to the isolation of seven compounds from the ethyl acetate extract using column chromatography and preparative TLC. The structures of these compounds were identified as, kaempferol-3-O-beta-D-glucopyranosyl (1rarr2)-O-beta-D-6- acetlyglucopyranoside (I), kaempferol-5-methylether (II), apigenin-5-O- [-L-Rhamnopyranosyl- (1rarr4)-beta-D-glucopyranoside]...
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