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Inclusions containing Fused in Sarcoma (FUS) are found in familial and sporadic cases of the incurable progressive motor neuron disease amyotrophic lateral sclerosis and in a common form of dementia, frontotemporal dementia. Most disease-associated mutations are located in the C-terminal proline–tyrosine nuclear localization sequence (PY-NLS) of FUS and impair its nuclear import. It has been shown...
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