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Background
While dysregulated sphingolipid metabolism has been associated with risk of childhood asthma, the specific sphingolipid classes and/or mechanisms driving this relationship remain unclear. We aimed to understand the multifaceted role between sphingolipids and other established asthma risk factors that complicate this relationship.
Methods
We performed targeted LC–MS/MS‐based quantification...
Background
The infant fecal microbiome is known to impact subsequent asthma risk, but the environmental exposures impacting this association, the role of the maternal microbiome, and how the microbiome impacts different childhood asthma phenotypes are unknown.
Methods
Our objective was to identify associations between features of the prenatal and early‐life fecal microbiomes and child asthma phenotypes...
Background
Intake of fish‐oil and fatty fish during pregnancy has been shown to reduce the risk of childhood asthma but biomarkers of such intake are lacking.
Objective
To establish biomarkers of prenatal fish‐oil exposure from newborn dry blood spot metabolomics profiles and assess their relevance for childhood asthma risk stratification.
Methods
The Danish COPSAC2010 mother–child cohort was...
Background
Early exposure to allergens through a defect skin barrier has been proposed as a mechanism for inducing sensitization and development of allergic diseases. We hypothesized that early‐onset, severe atopic dermatitis (AD) is associated with development of aeroallergen sensitization and allergic rhinitis.
Methods
We included 368 children from the Copenhagen Prospective Studies on Asthma...
Background
The immune system plays a key role in the pathogenesis of asthma and allergy, but the role of the airway cytokine and chemokine composition in vivo in early life prior to symptom development has not been described previously. Here, we aimed to examine whether the neonatal airway immune composition associates with development of allergy and asthma in childhood.
Methods
We measured unstimulated...
Background
Asthma‐like symptoms in young children are orchestrated by the local airway immune response, but current knowledge largely relies on in vitro airway models. Azithromycin has been shown to reduce the duration of episodes with asthma‐like symptoms, but efficacy may depend on the individual child's immune response.
Objectives
To investigate in vivo upper airway immune mediator levels during...
Current data indicate that the “bronchiolitis” diagnosis comprises more than one condition. Clinically, pathophysiologically, and even genetically three main clusters of patients can be identified among children suffering from severe bronchiolitis (or first wheezing episode): (a) respiratory syncytial virus (RSV)‐induced bronchiolitis, characterized by young age of the patient, mechanical obstruction...
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