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A defined mixture of rho iso-alpha-acids (RIAA), a modified hop extract, was evaluated for anti-inflammatory efficacy and safety. RIAA inhibited LPS-stimulated PGE 2 formation with >200-fold selectivity of COX-2 (IC 50 =1.3μg/ml) over COX-1 (IC 50 >289μg/ml). This occurred only when RIAA was added prior to, but not post, LPS stimulation. Consistent with this observation,...
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