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An ethanol extract of the fruit case of Garcinia mangostan, whose most abundant chemical species are xanthones, showed potent α-glucosidase inhibitory activity (IC 50 =3.2μg/ml). A series of isolated xanthones (1–16) demonstrated modest to high inhibition of α-glucosidase with IC 50 values of 1.5–63.5μM. In particular, one hitherto unknown xanthone 16 has a very rare 2-oxoethyl group...
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