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Cell culture-derived influenza vaccines (CCIVs) have several important advantages over egg-based influenza vaccines, including shorter production time, better preservation of wild-type virus antigenicity and large-scale production capacity.A randomized, double-blind, phase 3 trial was undertaken to evaluate the immunogenicity and safety of a novel cell culture-derived inactivated, subunit, trivalent...
We investigated whether healthy young (age⩽40) and elderly (age⩾65) people infected with cytomegalovirus (CMV) had similar levels of CD8 + T cell cytokine production and proliferation in response to an immunodominant CMV pp65 peptide pool given the role of CD8 + T cells in controlling viral infection and the association of CMV with immunosenescence. Plus, we determined the effects...
Th17 cells produce IL-17 that plays an important role in host defense. However, little is known about whether aging affects human Th17 cells. Here we demonstrated that healthy elderly people (age≥65) had a decreased frequency of IL-17-producing cells in memory CD4 + T cells compared to healthy young people (age≤40) while both groups had similar frequencies of IFN-γ-producing cells in the same...
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