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Expression of endothelial nitric oxide synthase (eNOS) has been localized to the villous syncytiotrophoblasts suggesting that NO release from these cells could prevent platelet adhesion and aggregation in the intervillous space. Hypoxia- or inflammation-dependent changes in the release of this vasoactive substance may result in thrombus formation and altered vascular resistance which occur in the...
Clinical and experimental evidence is consistent with a key role of point mutations of the p53 tumor suppressor gene in the etiology of squamous cell carcinoma. To determine the relation of tumor behavior and patient survival in vulvar cancer in regard to p53 status, we retrospectively analyzed 38 paraffin-embedded specimens of primary vulvar cancer for genetic alterations of exons 5–8 of the p53...
The Oxytocin receptor (OTR) concentration is suggested to be the most important regulating factor at the onset of labor. There is also evidence of local OT synthesis in amnion, chorion and decidua giving support to the presence of an autocrine or paracrine system for OT and its receptor. Sequencing of the OTR expressing gene made it possible to develop PCR systems. The aim of this study was to develop...
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