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Treatment of human myeloblastic leukemia ML-1 cells with the phorbol ester TPA in combination with the vitamin D 3 analogue KH1060 will induce a synergistic differentiation to mature macrophage with multinuclei. To investigate the mechanism underlying this differentiation and the synergistic effect, a cDNA microarray and Northern blot analysis were used to examine gene expression profiles...
We reported previously that diverse combination of the vitamin D 3 analogue KH1060 together with 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically induces the differentiation of ML-1 cells into mature macrophages. To investigate the mechanism involved in their interaction, we examined the role of protein kinase C (PKC) in the differentiation of ML-1 cells to mature macrophages. We...
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