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SB203580 is the prototypical p38 MAPK inhibitor; however it cannot be used clinically due to liver toxicity. We developed a structural analogue of SB203580 – ML3403 – with equal in vitro and ex vivo p38α MAPK inhibition as SB203580, but with reduced activity towards liver cytochrome P450 enzymes. In addition, we developed a selective p38α MAPK inhibitor — CP41. The aim of this study is to compare...
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