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Twenty-four structurally different SLs were studied for their inhibition on IL-8 production in HeLa229 cells and different IC 50 -values were obtained. QSAR analyses revealed that the α-methylene-γ-lactone and the presence and reactivity of a second reaction center, expressed by LUMO2, are the most important descriptors for IL-8. Using two SLs as examples, we demonstrated that SLs prevent...
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