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The antitumor agent, paclitaxel (Taxol ( R)), mimics the actions of lipopolysaccharide (LPS) on murine macrophages (Mφ). Various synthetic analogs of paclitaxel were examined for their potencies to induce nitric oxide (NO) and tumor necrosis factor (TNF) production by murine peritoneal Mφ, and by human peripheral blood cells. The benzoyl group at C-2, the hydroxy group at C-7 and the acetyl...
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