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Damage to the central or peripheral nervous system causes neuropathic pain. Endoplasmic reticulum (ER) stress plays a role in peripheral neuropathy. Increase in ER stress is seen in diabetic neuropathy. Inducers of ER stress also give rise to peripheral neuropathy. ER stress leads to the formation of autophagosome but as their degradation is also stalled during ER stress accumulation of autophagosomes...
Cellular stress like ER and oxidative stress are the principle causative agents of various proteinopathies. Multifunctional protein PARK7/DJ‐1 provides protection against cellular stress. Recently, insulin/IGF also has emerged as a neuro‐protective molecule. However, it is not known whether DJ‐1 and insulin/IGF complement each other for cellular protection in response to stress. In this study, we...
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