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Background
BT200, a pegylated form of the aptamer BT100, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis in cynomolgus monkeys. It is being developed for secondary prevention of arterial thrombosis such as stroke or myocardial infarction. Inhibition of thrombogenesis by BT200 is expected to provide a therapeutic benefit. However, there...
The summer minimum Arctic sea ice extent has long been used as a measure of climate change, with record lows being reported in recent years. Understanding the dynamics of the Arctic sea ice extent is of utmost importance in understanding the timescales associated with this change. Complex global climate models are typically employed to gain insights about the future of Arctic sea ice, however, these...
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