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The development of explosives detection technologies has increased significantly over the years as environmental and national security agencies implement tighter pollution control measures and methods for improving homeland security. 2, 4, 6-Trinitrotoluene (TNT), known primarily as a component in munitions, has been targeted for both its toxicity and carcinogenic properties that if present at high...
One of the most difficult aspects of maintaining port and maritime security is the detection, localization, and classification of submerged explosive devices, biochemical agents, and contraband including narcotics. The Explosives Ordnance Disposal (EOD) community has expressed the need for improved methods of detection to augment current capabilities. SubChem Systems Inc. and the U.S. Naval Research...
In this paper are the experimental results used to characterize four distinct monoclonal anti-TNT antibodies (in vivo and in vitro cloned) for potential use in a field-portable immunosensor. Direct and competitive enzyme-linked immunosorbent assays (ELISA) were performed to determine their affinity for TNT and a fluorescently labeled analog of TNT for use in an immunosensor. Effective concentrations...
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