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Rationale Asenapine, a novel psychopharmacologic agent in the development for schizophrenia and bipolar disorder, has high affinity for serotonergic, α-adrenergic, and dopaminergic receptors, suggesting potential for antipsychotic and cognitive-enhancing properties. Objectives The effects of asenapine in rat models of antipsychotic efficacy and cognition were examined and compared with those of...
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