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Introduction: Modulation of constitutive activity by the recombinant wild-type human 5-HT6 receptor was investigated with a series of 5-HT6 receptor ligands by monitoring the cAMP signalling pathway. The impact of the mutation S267K near the B 261 BXXB 265 CIII-loop motif was analyzed on the magnitude of constitutive receptor activity as previously conflicting results have been reported...
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