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A series of derivatives of 3′,4′ 0,0-didemethylpodophyllotoxin have been synthesized and evaluated for their inhibitor activity against neoplastic cell growth (KB) and against human DNA topoisomerase II as well as for their activity in causing cellular protein-linked DNA breakage. The results show that the compounds possessing a 4β-anilino moiety either unsubstituted or substituted at the para (F,...
A series of 4β-benzoylamino (5-17) derivatives of 4′-O-demethyl-4-desoxypodophyllotoxin and 4β-benzoyl (18-20) derivatives of 4′-O-demethyl podophyllotoxin have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity in causing cellular protein-linked DNA breakage. Compounds 5-13 and 15-17 are more potent than etoposide in causing...
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