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Mesolimbic dopaminergic neurotransmission is modulated by dynorphin peptides binding to κ-opioid receptors. The interaction between dynorphin and dopamine systems makes the κ-opioid receptor a potential drug discovery target for the development of therapeutic agents for schizophrenia and drug abuse. This study reports the specificity and parameters of [ 3 H]U69593 binding in the insular...
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