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The essential splicing factors U2AF 65 and SF1 cooperatively bind consensus sequences at the 3′ end of introns. Phosphorylation of SF1 on a highly conserved “SPSP” motif enhances its interaction with U2AF 65 and the pre-mRNA. Here, we reveal that phosphorylation induces essential conformational changes in SF1 and in the SF1/U2AF 65 /3′ splice site complex. Crystal structures...
Riboswitches “sense” metabolites but knowledge is sparse for structures without bound ligand. Stoddard et al. (2010) determined an apo riboswitch structure “closed” to metabolite binding. Further SAXS, biochemical, and computational analyses support ensemble behavior with interconverting open and closed conformations.
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