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Antisense oligonucleotides (AONs) targeted to the R-region near the 5 -LTR of HIV-1 genomic RNA inhibited both the synthesis of (-) strong stop DNA and the first template-switch reaction catalysed by HIV-1 reverse transcriptase (RT) in vitro. The 18 nucleotide (nt) AONs used were identical in sequence but differed in the sugar component of the 3 -terminal nucleotide, with either 2 -deoxy-d-ribose...
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