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Aims
To determine the role of p75 neurotrophin receptor (p75NTR) and the therapeutic effect of the selective small molecule p75NTR modulator, LM11A‐31, in spinal cord injury (SCI) induced lower urinary tract dysfunction (LTUD) using a mouse model.
Methods
Adult female T8‐T9 transected mice were gavaged daily with LM11A‐31 (100 mg/kg) for up to 6 weeks, starting 1 day before, or 7 days following...
Aim
To determine the efficacy of human relaxin‐2 (hRLX2) in reversing radiation‐induced bladder fibrosis and lower urinary tract dysfunction (LUTD). Radiation cystitis is a consequence of radiotherapy for pelvic malignancies. Acutely, irradiation leads to reactive oxygen/nitrogen species in urothelial cells, apoptosis, barrier disruption, and inflammation. Chronically, this results in collagen deposition,...
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