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Serum albumin is the major protein component of blood plasma and is responsible for the circulatory transport of a range of small molecules that include fatty acids, hormones, metal ions and drugs. Studies examining the ligand-binding properties of albumin make up a large proportion of the literature. However, many of these studies do not address the fact that albumin carries multiple ligands (including...
Histidine-rich glycoprotein (HRG) is a plasma adaptor protein involved in the formation of protein complexes that regulate a number of biological processes in the blood, most notably coagulation and the immune system. Elevated levels of HRG are clinically linked to thrombotic disorders such as blood vessel occlusion. A large body of evidence suggests that Zn 2+ ions stimulate HRG-complex formation;...
We report X-ray crystal structures of complexes of the membrane-permeable metal chelator N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) with Cu(II) and Zn(II), and solution studies of the Zn(II) and Cd(II) complexes. [Zn(II)(TPEN)](PF 6 ) 2 exhibits a distorted octahedral geometry with hexadentate TPEN, whilst [Cu(II)(TPEN)](PF 6 ) 2 contains penta-coordinated...
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