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Lampreys are one of the most primitive vertebrates diverged some 500 million years ago. It has long been known that parasitic lampreys secrete anticoagulant from their buccal glands and prevent blood coagulation of host fishes. We found two major protein components of 160 and 26kDa in the buccal gland secretion of parasitic river lamprey, Lethenteron japonicum. The larger protein was identified as...
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