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This study was conducted to investigate the agonistic activity against human retinoic acid receptor (RAR) α in the Lake Biwa–Yodo River and the Ina River in the Kinki region of Japan. To accomplish this, a yeast two-hybrid assay was used to elucidate the spatial and temporal variations and potential sources of RARα agonist contamination in the river basins. RARα agonistic activity was commonly detected...
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