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Hydroxyl radical (•OH) with strong oxidation capability is one of the most important reactive oxygen species. The generation of •OH from superoxide radicals (•O2−) is an important process in visible‐light‐driven photocatalysis, but the conversion generally suffers from slow reaction kinetics. Here, a hydrophobicity promoted efficient •OH generation in a visible‐light‐driven semiconductor‐mediated...
In view of the increased levels of reactive oxygen species (ROS) that disturb the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), the repair of diabetic bone defects remains a great challenge. Herein, a factor‐free hydrogel is reported with ROS scavenging and responsive degradation properties for enhanced diabetic bone healing. These hydrogels contain ROS‐cleavable thioketal...
Mitochondria are core regulators of tumor cell homeostasis, and their damage has become an arresting therapeutic modality against cancer. Despite the development of many mitochondrial‐targeted pharmaceutical agents, the exploration of more powerful and multifunctional medications is still underway. Herein, oxygen vacancy‐rich BiO2‐x wrapped with CaCO3 (named BiO2‐x@CaCO3/PEG, BCP) is developed for...
Based on the pathological characteristics of rheumatoid arthritis, including the overproduction of reactive oxygen species (ROS), inflammatory responses, and osteoclast differentiation, a biomimetic multifunctional nanomedicine (M‐M@I) is designed. Iguratimod (IGU) is loaded, which inhibits inflammatory responses and osteoclast differentiation, into mesoporous polydopamine (MPDA), which scavenges...
The contrast agents and tumor treatments currently used in clinical practice are far from satisfactory, due to the specificity of the tumor microenvironment (TME). Identification of diagnostic and therapeutic reagents with strong contrast and therapeutic effect remains a great challenge. Herein, a novel carbon dot nanozyme (Mn‐CD) is synthesized for the first time using toluidine blue (TB) and manganese...
Hepatic Ischemia‐Reperfusion Injury Management
Selenium‐doped carbon quantum dots (Se‐CQDs) with excellent anti‐oxidation capability protect hepatocytes from apoptosis by limiting damage from oxidative stress. Se‐CQDs‐lecithin nanoparticles are developed through a supramolecular self‐assembly mainly driven by noncovalent interactions, which effectively scavenge reactive oxygen species and inhibit...
Hepatic ischemia‐reperfusion injury (HIRI) is a critical complication after liver surgery that negatively affects surgical outcomes of patients with the end‐stage liver‐related disease. Reactive oxygen species (ROS) are responsible for the development of ischemia‐reperfusion injury and eventually lead to hepatic dysfunction. Selenium‐doped carbon quantum dots (Se‐CQDs) with an excellent redox‐responsive...
The therapeutic exploration of nano‐zirconia semiconductor largely remains untouched in the field of fundamental science to date. Here, a robust nano‐sonosensitizer of ZrO2−x@Pt is strategically formulated by in situ growth of Pt nanocrystal onto the surface of oxygen‐deficient ZrO2−x. Compared to 3.09 eV of nano‐ZrO2−x, the bandgap of ZrO2−x@Pt Schottky junction is narrowed down to 2.74 eV. The band...
Regulating the catalytic pathways of single‐atom sites in single atom catalysts (SACs) is an exciting debate at the moment, which has redirected the research towards understanding and modifying the single‐atom catalytic sites through various strategies including altering the coordination environment of single atom for desirable outcomes as well as increasing their number. One useful aspect concerning...
Nanozymes are widely applied for treating various major diseases, including neurological diseases and tumors. However, the biodegradability of nanozymes remains a great challenge, which hinders their further clinical translation. Based on the microenvironment of osteoarthritis (OA), a representative pH‐responsive biodegradable hollow‐structured manganese Prussian blue nanozyme (HMPBzyme) is designed...
Antibacterial Effects
In article number 2200548, Xu Yu, Li Xu, Itamar Willner, and co‐workers show that the Au3+‐metal‐organic framework nanoparticles (NMOFs) nanozymes reveal dual oxidase‐like and peroxidase‐like activities and act as an active catalyst for the catalyzed generation of O2•− under aerobic conditions or •OH in the presence of H2O2. The two reactive oxygen species agents cooperatively...
The synthesis and characterization of Au3+‐modified UiO‐67 metal‐organic framework nanoparticles, Au3+‐NMOFs, are described. The Au3+‐NMOFs reveal dual oxidase‐like and peroxidase‐like activities and act as an active catalyst for the catalyzed generation of O2•− under aerobic conditions or •OH in the presence of H2O2. The two reactive oxygen species (ROS) agents O2•− and •OH are cooperatively formed...
Excess generation of reactive oxygen species (ROS) based on sensitizers under ultrasound (US) excitation can cause the death of tumor cells via oxidative damage, but sonosensitizers are largely unexplored. Herein, oxygen‐deficient black BiOCl (B‐BiOCl) nanoplates (NPs) are reported, with post‐treatment on conventional BiOCl by simple UV excitation, showing stronger singlet oxygen (1O2) generation...
Macrophage polarization toward M1 phenotype (pro‐inflammation) is closely associated with the destructive phase of periodontal inflammation. Nanoceria is verified to inhibit M1 polarization of macrophages by the favorable ability of reactive oxygen species (ROS) scavenging. However, the function of nanoceria on macrophage polarization toward M2 phenotype (anti‐inflammation) in reparative phase of...
Spinal cord injury (SCI) is a devastating disorder, leading to permanent motor and sensory deficit. Despite recent advances in neurosciences, the treatment efficacy on SCI patients remains unsatisfactory, mainly due to the poor accumulation, short retention, and lack of controlled release of therapeutics in lesion tissue. Herein, an injured spinal cord targeting prodrug polymer micelle is built. An...
Lactic acid (LA) is a powerful molecule as the metabolic driver in tumor microenvironments (TMEs). Inspired by its high intratumoral level (5–20 µmol g−1), a novel treatment paradigm via the cascade release of H2O2 and ·OH from the LA generated by tumor metabolism is developed for catalytic and pH‐dependent selective tumor chemotherapy. By utilizing the acidity and overexpression of LA within the...
Singlet oxygen (1O2), as an important kind of reactive oxygen species (ROS) and main therapeutic agent in photodynamic therapy (PDT), only have a half‐life of 40 ns and an effective radius of 20 nm, which cause significant obstacles for improving PDT efficacy. In this work, novel upconversion nanoparticle (UCN)‐based nanoplatforms are developed with a minimized distance between UCNs and a photosensitizer,...
In article number 1602053, Ke Tao, Guangdong Zhou, Kang Sun and co‐workers novel nanoplatforms for photodynamic therapy (PDT) are developed. By targeting the reactive oxygen species (ROS) producing nanoplatform at mitochondria sites a more significant enhancement of the photodynamic therapy efficacy is demonstated. The findings may provide a novel strategy for designing nanomedicines for PDT.
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