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Cancer Immunotherapy
In article number 2308731, Bing Liu, Chun Xu, Lin‐Lin Bu, and co‐workers explore the innovative use of nanoparticles for targeted drug delivery to lymph nodes, aiming to activate the immune system in the battle against cancer. The image interprets the physiological process of nanoparticles targeting lymph nodes for drug delivery as an approach in immunotherapy.
Immunotherapy has emerged as a potent strategy in cancer treatment, with many approved drugs and modalities in the development stages. Despite its promise, immunotherapy is not without its limitations, including side effects and suboptimal efficacy. Using nanoparticles (NPs) as delivery vehicles to target immunotherapy to lymph nodes (LNs) can improve the efficacy of immunotherapy drugs and reduce...
Functional metamaterials can be constructed by assembling nanoparticles (NPs) into well‐ordered structures, which show fascinating properties at different length scales. Using polymer‐grafted NPs (PGNPs) as a building block, flexible composite metamaterials can be obtained, of which the structure is significantly affected by the property of polymer ligands. Here, it is demonstrated that the crystallization...
Nanoparticles form long‐range micropatterns via self‐assembly or directed self‐assembly with superior mechanical, electrical, optical, magnetic, chemical, and other functional properties for broad applications, such as structural supports, thermal exchangers, optoelectronics, microelectronics, and robotics. The precisely defined particle assembly at the nanoscale with simultaneously scalable patterning...
Mesenchymal stem cells (MSCs) are becoming hotspots for application in disease therapies recently, combining with biomaterials and drug delivery system. A major advantage of MSCs applied in drug delivery system is that these cells enable specific targeting and releasing of cargos to the disease sites. However, the potential tumor tropic effects of MSCs raised concerns on biosafety. To solve this problem,...
The asialoglycoprotein receptor (ASGPR) is expressed in high density on hepatocytes. Multivalent variants of galactosyl carbohydrates bind ASGPR with high affinity, enabling hepatic delivery of ligand‐bound cargo. Virus‐like particle (VLP) conjugates of a relatively high‐affinity ligand were efficiently endocytosed by ASGPR‐expressing cells in a manner strongly dependent on the nature and density...
Biomimetic Nanoparticles
In article number 2301439, Rutong Yu, Xiuping Zhou, and co‐workers construct a Trojan‐horse‐like nanoparticle system (R‐NKm@NPs), which traverses across the blood‐brain barrier (BBB) and targets glioblastoma through the natural killer (NK) cell membrane decorated with cRGD. Notably, the R‐NKm@NPs exhibit good antitumor ability by locally releasing temozolomide (TMZ) and IL‐15,...
Although the chemo‐ and immuno‐therapies have obtained good responses for several solid tumors, including those with brain metastasis, their clinical efficacy in glioblastoma (GBM) is disappointing. The lack of safe and effective delivery systems across the blood‐brain barrier (BBB) and the immunosuppressive tumor microenvironment (TME) are two main hurdles for GBM therapy. Herein, a Trojan‐horse‐like...
Ligand‐Free PtAg Nanoalloys
In article number 2206772, Indranath Chakraborty and co‐workers use the atomic pair‐distribution function combined with powder X‐ray diffraction and transmission electron microscopy for structural analysis of ligand‐free PtAg nanoclusters (NCs). They further investigate the intrinsic enzyme‐mimicking properties of these ligand‐free NCs and explored the mechanistic details...
Nanozymes are nanomaterials with biocatalytic properties under physiological conditions and are one class of artificial enzymes to overcome the high cost and low stability of natural enzymes. However, surface ligands on nanomaterials will decrease the catalytic activity of the nanozymes by blocking the active sites. To address this limitation, ligand‐free PtAg nanoclusters (NCs) are synthesized and...
Neuroblastoma Therapy
In article number 2201671, Zhen Liu and co‐workers construct polysialic acid‐targeting nano‐missiles via a molecular imprinting strategy using oligosialic acid containing 4‐7 units digested from polySia as the template. Effective targeted photothermal therapy of neuroblastoma is achieved using nano‐missiles loaded with the near‐infrared fluorescent reactive dye indocyanine green...
Exploring new targets and developing novel targeted therapies are urgently needed for neuroblastoma therapy. Polysialic acid (polySia), a linear homopolymer of sialic acid units that correlates well with tumor progression and poor prognosis, has emerged as a potential target for neuroblastoma. However, the lack of polySia‐specific binding reagents has severely limited the development of polySia‐targeting...
Helicene‐based therapeutic agents for organelle‐targeted photodynamic therapy (PDT) involving both type I and II are challenging and still underexplored. Herein, water‐soluble nanoparticles containing twisted double [7]carbohelicene (D7H‐NPs) are prepared through self‐assembly with 1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐N‐[methoxy(polyethylene glycol)‐2000] by a nanoprecipitation method....
3D printing (additive manufacturing (AM)) has enormous potential for rapid tooling and mass production due to its design flexibility and significant reduction of the timeline from design to manufacturing. The current state‐of‐the‐art in 3D printing focuses on material manufacturability and engineering applications. However, there still exists the bottleneck of low printing resolution and processing...
A new strategy for retaining long‐range order during ligand exchange of nanocrystal superlattices is used to construct PbSe infrared photodetectors by Christine Orme and co‐workers (article number 2101166). The ordered photodetectors have a 16× higher responsivity and 2× faster response time compared to disordered ones.
Colloidal semiconductor nanocrystals are important building blocks for low‐cost, solution‐processed electronic devices with tunable functionalities. Considerable progress is made in improving charge transport through nanocrystal films by exchanging long insulating ligands with shorter passivating ligands. To take full advantage of this strategy, it is equally important to fabricate close‐packed structures...
Atherosclerosis, characterized by endothelial injury, progressive inflammation, and lipid deposition, can cause cardiovascular diseases. Although conventional anti‐inflammatory drugs reveal a certain amount of therapeutic effect, more reasonable design on plaque targeting, local anti‐inflammation, and lipid removal are still required for comprehensive atherosclerosis therapy. In this work, a theranostic...
Engineering a facile and controllable approach to modulate the spectral properties of lanthanide‐doped upconversion nanoparticles (UCNPs) is always an ongoing challenge. Herein, long‐range ordered, distinct two‐dimensional (2D) binary nanoparticle superlattices (BNSLs) composed of NaREF4:Yb/Er (RE = Y and Gd) UCNPs and plasmonic metallic nanoparticles (Au NPs), including AB, AB3, and AB13 lattices,...
Defined hierarchical materials promise cell analysis and call for application‐driven design in practical use. The further issue is to develop advanced materials and devices for efficient label‐free cell capture with minimum instrumentation. Herein, the design of hierarchical beads is reported for efficient label‐free cell capture. Silica nanoparticles (size of ≈15 nm) are coated onto silica spheres...
In article number 1902441, Kun Qian and co‐workers design hierarchical beads for label‐free cell capture. Silica nanoparticles are coated on silica spheres for surface roughness and then combined with microbeads to assemble hierarchical structures. Functionalized by hyaluronic acid, the hierarchical beads display desirable structural parameters with high cell capture efficiency.
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