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Emerging evidence has demonstrated the significant contribution of mitochondrial metabolism dysfunction to promote cancer development and progression. Aberrant expression of mitochondrial genome (mtDNA)‐encoded proteins widely involves mitochondrial metabolism dysfunction, and targeted regulation of their expression can be an effective strategy for cancer therapy, which however is challenged due to...
The field of nanozymes has developed rapidly over the past decade. Among various oxidoreductases mimics, catalase (CAT)‐like nanozyme, acting as an essential part of the regulation of reactive oxygen species (ROS), has attracted extensive research interest in recent years. However, CAT‐like nanozymes are not as well discussed as other nanozymes such as peroxidase (POD)‐like nanozymes, etc. Compared...
Regulation of angiogenesis is a great challenge for effective anticancer therapy. Generally, anti‐angiogenic therapies are focused on inhibition of inducers involved in pro‐angiogenic communication pathways. Despite the great potential of anti‐angiogenic therapy, engineering efficient angiogenesis inhibition agents (AIAs) is still a formidable challenge, since most anti‐angiogenic therapies are limited...
In article number 1906644, Guoqing Pan and co‐workers comprehensively discuss the recent progress of molecularly imprinted synthetic antibodies (MISAs) from fundamental chemical design to their emerging biomedical applications. Meanwhile, the possibility of MISAs as qualified substitutes or even to transcend the performance of natural antibodies is discussed from the perspective of frontier needs...
Billions of dollars are invested into the monoclonal antibody market every year to meet the increasing demand in clinical diagnosis and therapy. However, natural antibodies still suffer from poor stability and high cost, as well as ethical issues in animal experiments. Thus, developing antibody substitutes or mimics is a long‐term goal for scientists. The molecular imprinting technique presents one...
Iridium(III) complexes are potent candidates for photodynamic therapy. However, their clinical usage is impeded by their poor water solubility, high dark toxicity, and negligible absorption in near‐infrared region (NIR region). Here, it is proposed to solve these challenges by developing an iridium(III) complexe‐based polymeric micelle system. This system is self‐assembled using an iridium(III) complex‐containing...
Biodegradable polymeric nanoparticles (NPs) have demonstrated significant potential to improve the systemic delivery of RNA interference (RNAi) therapeutics, such as small interfering RNA (siRNA), for cancer therapy. However, the slow and inefficient siRNA release inside tumor cells generally observed for most biodegradable polymeric NPs may result in compromised gene silencing efficacy. Herein, a...
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