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To study the effects of reduced lipoic acid gene expression on diabetic atherosclerosis in apolipoprotein E null mice (Apoe −/− ).Heterozygous lipoic acid synthase gene knockout mice (Lias +/− ) crossed with Apoe −/− mice were used to evaluate the diabetic effect induced by streptozotocin on atherosclerosis in the aortic sinus of the heart. While diabetes markedly increased...
To evaluate the effects of a genetic reduction of Lias gene expression on atherosclerosis development.Heterozygous knockout mice for the lipoid acid synthase gene (Lias +/− ) were crossed with apolipoprotein E-deficient (ApoE −/− ) mice, and the plaque size in aortic sinuses of Lias +/− ApoE −/− mice was evaluated at 6 months of age. Lesions at the aortic sinus in Lias...
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