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We examined the effect of propofol and thiopental, intravenous anesthetics, on the hyperpolarization-activated inward current (IH), whose functional role on the neuronal activity has been evaluated. Whole-cell recordings of IH evoked by hyperpolarizing step pulses were taken from hippocampal CA1 neurons in rat brain slices. Propofol reduced IH current in a dose-dependent manner. However, thiopental...
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