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Objective
To explore the role of miR‐181b in alterations of apoptosis and autophagy in the kainic acid (KA)‐induced epileptic juvenile rats via modulating TLR4 and P38/JNK signaling pathway.
Methods
Dual‐luciferase reporter assay was performed to testify the targeting relationship between miR‐181b and TLR4. After intracerebroventricular injection (i.c.v.) of KA, rats were injected with miR‐181b...
AimsMcl‐1, an antiapoptotic member of the Bcl‐2 family, is overexpressed in human glioblastoma, conferring a survival advantage to tumor cells. The mechanisms underlying its dysregulation have not been clarified. In this study, we explored the involvement of micro‐RNAs that acted as endogenous sequence‐specific suppressors of gene expression.
Methods and resultsUsing computational and TCGA analysis,...
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