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Metacaspases are cysteine peptidases that are distantly related to the caspases, for which proteolytic processing is central to their activation. Here, we show that recombinant metacaspase 2 (MCA2) from Trypanosoma brucei has arginine/lysine-specific, Ca 2+ -dependent proteolytic activity. Autocatalytic processing of MCA2 occurred after Lys55 and Lys268; however, this was shown not to be required...
Neurolysin (EP24.16) and thimet oligopeptidase (EP24.15) are closely related metalloendopeptidases. Site-directed mutagenesis of Tyr 613 (EP24.16) or Tyr 612 (EP24.15) to either Phe or Ala promoted a strong reduction of k cat /K M for both enzymes. These data suggest the importance of both hydroxyl group and aromatic ring at this specific...
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