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This study aims to evaluate the renoprotective effect of betulin and the possible mechanisms in septic rats.In the animal study, rats underwent cecal ligation and puncture (CLP) were used as septic models. Betulin 4mg/kg or 8mg/kg was administrated intraperitoneally immediately after the model establishment. In the cell study, lipopolysaccharide (LPS) stimulated rat HBZY-1 mesangial cells were used...
Valproic acid (VPA), a histone deacetylase inhibitor, has extensive activities against inflammation, oxidation, and malignancy. This study was designed to investigate the protective effect of VPA on the systemic inflammatory response and renal injury in septic mice.The septic model of mice was established using a cecal ligation–puncture technique. A single dose of VPA (300 mg/kg) was administered...
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