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This study aims to evaluate the renoprotective effect of betulin and the possible mechanisms in septic rats.In the animal study, rats underwent cecal ligation and puncture (CLP) were used as septic models. Betulin 4mg/kg or 8mg/kg was administrated intraperitoneally immediately after the model establishment. In the cell study, lipopolysaccharide (LPS) stimulated rat HBZY-1 mesangial cells were used...
Polyinosinic polycytidylic acid (poly I:C) is an analog of double stranded RNA, which is a common replication intermediate for many viruses. It acts through a toll-like receptor (TLR3) to induce a group of cytokines that can mediate host resistance to viruses and some cancers. The effect of ethanol (EtOH) on induction of this set of cytokines has not been determined. Mice were treated with a single...
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