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Troponin C (TnC), a calcium-binding protein of the thin filament of muscle, plays a regulatory role in skeletal and cardiac muscle contraction. NMR reveals a small conformational change in the cardiac regulatory N-terminal domain of TnC (cNTnC) on binding of Ca 2+ such that the total exposed hydrophobic surface area increases very slightly from 3090 ± 86 Å 2 for apo-cNTnC to 3108 ±...
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