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Most of the endogenous opioids that have been identified are peptides that originate from four distinct precursor proteins, proenkephalin, prodynorphin, proopiomelanocortin (POMC), and pronociceptin/orphanin FQ. All four of these precursors are differentially processed by endopeptidases and carboxypeptidases to give rise to a large number of peptides that have biological activity. In many cases, the...
Neuropeptides serve many important roles in communication between cells and are an attractive target for drug discovery. Neuropeptides are produced from precursor proteins by selective cleavages at specific sites, and are then broken down by further cleavages. In general, the biosynthetic cleavages occur within the cell and the degradative cleavages occur postsecretion, although there are exceptions...
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