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When seizures, abnormal electrical discharges in the brain, occur during infancy or early childhood, there is a belief amongst child neurologists and pediatricians that the seizures are harmful to a child’s brain development. Anti-epileptic drugs are used to treat these seizures, yet these drugs may have an impact on brain development as well. Animal research has begun to address the questions “do...
Background Aristaless-related homeobox (ARX) is a paired-like homeodomain transcription factor that functions primarily as a transcriptional repressor and has been implicated in neocortical interneuron specification and migration. Given the role interneurons appear to play in numerous human conditions including those associated with ARX mutations, it is essential to understand the consequences of...
We used Northern analyses, RNase protection assays and immunoblot analyses to examine the relationship among developmental age of the heart, abundance of mRNA and L-type calcium channel α1Csubunit protein, and to establish the size of the native protein in heart. Northern analysis, RNase protection assays, and immunoblots were used to study RNA and protein from rat heart of various ages. In fetal...
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