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The International Society for Fracture Repair convened a multidisciplinary workshop to assess the current evidence around the interaction between anti-osteoporosis drugs and the healing of incident fractures, with a view to making recommendations for clinical practice. The consensus was that there is no evidence-based reason to withhold anti-resorptive therapy while a fracture heals, whether or not...
Some nonunion fractures are infected with biofilm-forming Staphylococcus epidermidis (SE). We examined the effect of biofilms from several staphylococcal species on the in vitro proliferation of HOP. HOP were incubated with biofilm (5.0 mg/ml) at a range of dilutions for 48 hours. HOP were also cultured on coverslips/wells coated with biofilm. The effect of biofilms on HOP numbers, alkaline phosphatase...
We have studied the time course of mRNA expression for collagens type I, II, IX and X, osteocalcin, BMP2 by in-situ hybridisation by cells in the early stages of periosteal bone formation in 30 human fractures, 24 rabbit laminectomies and 25 rats with type II collagen induced tenosynovitis.5um formalin fixed, EDTA decalcified, paraffin embedded serial sections were stained H and E and toluidine blue...
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