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BackgroundThe pH‐sensitive Helicobacter pylori ArsRS two‐component system (TCS) aids survival of this neutralophile in the gastric environment by directly sensing and responding to environmental acidity. ArsS is required for acid‐induced trafficking of urease and its accessory proteins to the inner membrane, allowing rapid, urea‐dependent cytoplasmic and periplasmic buffering. Expression of ArsR,...
Helicobacter pylori infects half of the world’s population and plays a causal role in ulcer disease and gastric cancer. This pathogenic neutralophile uniquely colonizes the acidic gastric milieu through the process of acid acclimation. Acid acclimation is the ability of the organism to maintain periplasmic pH near neutrality in an acidic environment to prevent a fall in cytoplasmic pH in order to...
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