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CCN proteins are modular multifunctional proteins comprised of four discrete domains: (1) an IGFBP domain, (2) a VWC domain, (3) a TSP domain, and (4) a CT domain. These domains give a broad repertoire of functions to the CCN family including angiogenesis, skeletal development tumourigenesis, wound healing, cell proliferation, adhesion and survival. These wide variety of biological functions are enabled...
The CCN family of proteins (CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6) are multifunctional mosaic proteins that play keys roles in crucial areas of physiology such as angiogenesis, skeletal development tumourigenesis, cell proliferation, adhesion and survival. This expansive repertoire of functions comes through a modular structure of 4 discrete domains that act both independently and in concert. How...
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