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We have identified a novel CARD-containing protein from EST database, BinCARD (Bcl10-interacting protein with CARD). BinCARD was ubiquitously expressed. Co-immunoprecipitation, In vitro binding, mammalian two-hybrid, and immunostaining assays revealed that BinCARD interacted with Bcl10 through CARD. BinCARD potently suppressed NF-κB activation induced by Bcl10 and decreased the amounts of phosphorylated...
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